Well, Grig Gheorghiu just posted the list of invited speakers for PyCon 2010, with their chosen topics. It's a doozie:
Ian Bicking: On the Subject of Source Code
Jeff Rush: Interfaces, Adapters and Factories
Jack Diederich: Python's Dusty Corners
Mike Fletcher: Debating 'til Dawn: Topics to Keep You Up All Night
Raymond Hettinger: Mastering Team Play: Four Powerful Examples of Composing Python Tools
Bob Ippolito: The Other Kind of Testing
Alex Martelli: Powerful Pythonic Patterns
Joe Gregorio: Threading is Not a Model
Ned Batchelder: Tests and Testability
Holger Krekel: The Ring of Python
Ted Leung: A Survey of Concurrency Constructs
More details on the PyCon web site. If PyCon only had those talks it would make an amazing one-day event, but of course there will be three days of talks, with four tracks, so in practice it will be completely impossible for anyone to attend all the talks that they would like to.
That's where the Pycon videos come in - high quality recordings of every scheduled talk will be available. It's nowhere near as good as being there, but if you were at PyCon it's a great way to fill in the gaps, and if you weren't then it's a good reminder of exactly why you should be next time around.
PyCon is a great conference. I'm looking forward to it already!